Professor Enrique Amaya has demonstrated that reactive oxygen species (ROS) are required for cell proliferation, growth factor signalling, and metabolic programming.

ROS are needed for cellular regeneration and tissue repair, which is stopped in the absence of reactive oxygen. Elevated and sustained ROS levels have been shown to facilitate mesoderm formation during early Xenopus development. Furthermore, Ca2+ induced mitochondrial ROS regulate the early embryonic cell cycle.

Work is currently looking at PK/PD for RO® in in vitro and ex vivo human cell lines and in laboratory animals.

EVERY organism that has high regenerative capacity, uses sustained ROS to regenerate…. we now also know that the capacity to regenerate organs, including the heart and liver, also use ROS. The short answer is that, if one wishes to regenerate, it is quite clear that being able to control ROS levels will be part of the key (if not the most important part).

Enrique Amaya
Prof Enrique Amaya

Figure 1 Nature

Amputated tailRegrown tail

By using light techniques, the presence of Reactive Oxygen® in tissue is shown in red. On amputation, the red continues to move with the new tissue being regenerated as a new tail forms.