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On 27 February 2017, the World Health Organization published its first-ever list of antibiotic-resistant “priority pathogens” – a catalogue of 12 families of bacteria that pose the greatest threat to human health.
Antimicrobial resistance is one of the most urgent health risks of our time and threatens to undo a century of medical progress.
The development of multi-drug resistance in already difficult to treat pathogens has prompted the WHO to declare a list of crisis bacteria.
Matoke’s Reactive Oxygen® technology has been shown to be active against all these crisis bacteria through different laboratories including Public Health England.
Time kill data showing in vitro efficacy Reactive Oxygen®. Microbiology testing and analysis conducted by Public Health England at Porton Down.
Reactive Oxygen® technology has been used with great success in a considerable number of clinical cases and in a wide variety of clinical settings.
A 77 year old patient with peripheral vascular disease presented with an infected sloughy discharging leg ulcer which was not healing. Samples were collected for microbiology and the ulcer washed with saline to remove slough. The microbiology sample showed a mixed growth of organsims which included MRSA, resistant coliforms and Pseudomonas aeruginosa. The vascular surgery team were keen to start broad spectrum intravenous antibiotics with meropenem (a last resort agent). As the patient did not have sepsis or spreading infection, antibiotics were withheld and topical treatment with Reactive Oxygen® was commenced. By day 10 the ulcer was clean and showed health healing granulation tissue.
Dryden M, Milward G, Saeed K. Infection prevention in wounds with Surgihoney.
J Hosp Infect. 2014 Oct;88(2):121-2. doi: 10.1016/j.jhin.2014.07.008. Epub 2014 Aug 1.
A neonate who had had abdominal surgery shows (Day 0) early infection and granuloma caused by MRSA at the edge of the wound.
The wound was treated regularly with only Reactive Oxygen® without systemic antibiotics. The result by day 19 was complete healing with scarring and eradication of MRSA.
A 70 year old patient had returned from India and diagnosed with necrotising fasciitis.
Surgical debridement and IV antibiotics to treat causative organisms Staph. aureus and Strep.pyogenes. Soft tissue also colonised with pan-resistant Klebsiella pneumoniae exhibiting NDM and OXA 48 beta lactamases in urine and soft tissue. Soft tissue treated with Reactive Oxygen®.
Dryden M, Milward G, Saeed K. Infection prevention in wounds with Surgihoney.
J Hosp Infect. 2014 Oct;88(2):121-2. doi: 10.1016/j.jhin.2014.07.008. Epub 2014 Aug 1.
Swabs showed complete eradication of the multiply resistant Gram-negatives which would have presented a major infection control risk to the hospital. The wound was successfully resolved and avoided limb amputation.
Dryden M, Milward G, Saeed K. Infection prevention in wounds with Surgihoney.
J Hosp Infect. 2014 Oct;88(2):121-2. doi: 10.1016/j.jhin.2014.07.008. Epub 2014 Aug 1.
A 48 year old business executive with breast cancer had a central vascular long line in place for chemotherapy. After a work trip to Greece, the patient presented to the clinic, concerned about redness around the line exit site.
A microbiological sample showed a pan-resistant Klebsiella pneumonia (carbapenemase producer). There was a risk of bacteraemia and sepsis from the line with little option to treat with antibiotics. The patient was likely to become more immunosuppressed around the next round of chemotherapy.
The line site was treated with Reactive Oxygen®. The redness settled and the multi-resistant organism was eradicated.
Dryden M, Milward G, Saeed K. Infection prevention in wounds with Surgihoney.
J Hosp Infect. 2014 Oct;88(2):121-2. doi: 10.1016/j.jhin.2014.07.008. Epub 2014 Aug 1.
An 18-year-old girl run over by a tractor suffered multiple fractures of the tibia. Image 1 shows that the soft tissue has become heavily colonised and infected with resistant coliforms and there is a risk of infection proceeding down the pins which could result in infection of the bone and loss of the limb.
After daily treatment of the soft tissue with Reactive Oxygen®, image 2 shows a reduction in inflammation, control of microbial growth and prevention of deep seating infection.
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1. The introduction of the halogen, iodine, to control wound infection during the American Civil War (1861-1865).
2. The recognition of the need to create an aseptic wound environment, led by Johnson and Johnson. Inspired by a speech by antiseptic advocate Joseph Lister, Robert Wood Johnson and his brothers created a line of ready-to-use surgical dressings in 1885.
3. The introduction of the heavy metal, silver, to control battlefield wound infections in the First World War. Subsequently, other heavy metals, like mercury have been used but are now seen as just too toxic.