What is it?

Reactive Oxygen® represents an innovative new generation of antimicrobials, which harnesses a natural human biological defence mechanism.

Reactive Oxygen® is naturally-occurring in all organisms and has effectively been aiding the healing process and fighting infections without resistance development for millions of years. Reactive oxygen species (ROS) are a group of chemically active molecules and atoms containing oxygen, such as peroxides, superoxide, hydroxyl radical and oxygen free radicals.

Reactive Oxygen® is an example of a reactive radical and is a single oxygen atom. In a biological context, ROS and Reactive Oxygen®, are formed as a natural product by the breakdown of organic compounds containing oxygen. Matoke® Holdings Ltd has observed and learned to control Reactive Oxygen®, optimising its delivery to the infection site, harnessing it through treatment platforms to fight infections effectively and promote wound care. It can be used to enhance natural defence mechanisms against infections. The formulations are economical to produce, transport, store and administer, and are applicable in all health economies.

How does it work?

An elderly lady with a chronic ulcer on the dorsum of her foot. She was admitted to hospital for more intensive wound care and because the patient not coping at home.

The application of Matoke’s Reactive Oxygen® technology helped stimulate the 5 key elements of healing below to resolve this long-term problem.

Picture1 Day 0
1

Haemostasis

Early ROS mediated vasoconstriction following platelets exposure to ECM/collagen plus platelet and thrombin activation to induce thrombus formation

1
2

Lymphocyte recruitment

Rapid migration of neutrophils from local blood vessels towards the injury site via ROS signalling

2
3

Pathogen defence

Killing of bacteria and fungi by ROS driven phagocytosis and bacteriostatic RO release by platelets and neutrophils

3
4

Lymphocyte recruitment

Migration of monocytes towards the wound site via ROS signalling

4
5

Tissue repair

ROS mediated cell division and migration of Keratinocytes, Endothelial (angiogenesis) and fibroblasts and collagen formation

5
Dunnill C, Patton T, Brennan J, et al. Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS-modulating technologies for augmentation of the healing process. International Wound Journal 2015;14:89-96.”

The ulcer has responded well to daily dressing with Reactive Oxygen®. There is less slough, discharge and inflammation. Reactive Oxygen® has provided a catalyst for healing and microbial control. This could have been delivered at home and saved a hospital admission.

After Day 11

Evidence